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Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

ABSTRACT: Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.

SUBMITTER: Schumacher FR 

PROVIDER: S-EPMC4967357 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Genome-wide association study of colorectal cancer identifies six new susceptibility loci.

Schumacher Fredrick R FR   Schmit Stephanie L SL   Jiao Shuo S   Edlund Christopher K CK   Wang Hansong H   Zhang Ben B   Hsu Li L   Huang Shu-Chen SC   Fischer Christopher P CP   Harju John F JF   Idos Gregory E GE   Lejbkowicz Flavio F   Manion Frank J FJ   McDonnell Kevin K   McNeil Caroline E CE   Melas Marilena M   Rennert Hedy S HS   Shi Wei W   Thomas Duncan C DC   Van Den Berg David J DJ   Hutter Carolyn M CM   Aragaki Aaron K AK   Butterbach Katja K   Caan Bette J BJ   Carlson Christopher S CS   Chanock Stephen J SJ   Curtis Keith R KR   Fuchs Charles S CS   Gala Manish M   Giovannucci Edward L EL   Gogarten Stephanie M SM   Hayes Richard B RB   Henderson Brian B   Hunter David J DJ   Jackson Rebecca D RD   Kolonel Laurence N LN   Kooperberg Charles C   Küry Sébastien S   LaCroix Andrea A   Laurie Cathy C CC   Laurie Cecelia A CA   Lemire Mathieu M   Levine David D   Ma Jing J   Makar Karen W KW   Qu Conghui C   Taverna Darin D   Ulrich Cornelia M CM   Wu Kana K   Kono Suminori S   West Dee W DW   Berndt Sonja I SI   Bezieau Stéphane S   Brenner Hermann H   Campbell Peter T PT   Chan Andrew T AT   Chang-Claude Jenny J   Coetzee Gerhard A GA   Conti David V DV   Duggan David D   Figueiredo Jane C JC   Fortini Barbara K BK   Gallinger Steven J SJ   Gauderman W James WJ   Giles Graham G   Green Roger R   Haile Robert R   Harrison Tabitha A TA   Hoffmeister Michael M   Hopper John L JL   Hudson Thomas J TJ   Hudson Thomas J TJ   Jacobs Eric E   Jacobs Eric E   Iwasaki Motoki M   Jee Sun Ha SH   Jenkins Mark M   Jia Wei-Hua WH   Joshi Amit A   Li Li L   Lindor Noralene M NM   Matsuo Keitaro K   Moreno Victor V   Mukherjee Bhramar B   Newcomb Polly A PA   Potter John D JD   Potter John D JD   Raskin Leon L   Rennert Gad G   Rosse Stephanie S   Severi Gianluca G   Schoen Robert E RE   Seminara Daniela D   Shu Xiao-Ou XO   Slattery Martha L ML   Tsugane Shoichiro S   White Emily E   Xiang Yong-Bing YB   Zanke Brent W BW   Zheng Wei W   Le Marchand Loic L   Casey Graham G   Gruber Stephen B SB   Peters Ulrike U  

Nature communications 20150707

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide  ...[more]

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