Trajectories of self-reported cognitive function in postmenopausal women during adjuvant systemic therapy for breast cancer.

ABSTRACT:

Objective

In a sample of 368 postmenopausal women, we (1) determined within-cohort and between-cohort relationships between adjuvant systemic therapy for breast cancer and self-reported cognitive function during the first 18 months of therapy and (2) evaluated the influence of co-occurring symptoms, neuropsychological function, and other covariates on relationships.

Methods

We evaluated self-reported cognitive function, using the Patient Assessment of Own Functioning Inventory (PAOFI), and potential covariates (e.g., co-occurring symptom scores and neuropsychological function z-scores) in 158 women receiving aromatase inhibitor (AI) therapy alone, 104 women receiving chemotherapy followed by AI therapy, and 106 non-cancer controls. Patients were assessed before systemic ther

SUBMITTER: Merriman JD 

PROVIDER: S-EPMC4969219 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature