MetaboTools: A Comprehensive Toolbox for Analysis of Genome-Scale Metabolic Models.

ABSTRACT: Metabolomic data sets provide a direct read-out of cellular phenotypes and are increasingly generated to study biological questions. Previous work, by us and others, revealed the potential of analyzing extracellular metabolomic data in the context of the metabolic model using constraint-based modeling. With the MetaboTools, we make our methods available to the broader scientific community. The MetaboTools consist of a protocol, a toolbox, and tutorials of two use cases. The protocol describes, in a step-wise manner, the workflow of data integration, and computational analysis. The MetaboTools comprise the Matlab code required to complete the workflow described in the protocol. Tutorials explain the computational steps for integration of two different data sets and demonstrate a comprehensi

SUBMITTER: Aurich MK 

PROVIDER: S-EPMC4971542 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature