Wnt signal transduction pathways: modules, development and evolution.

ABSTRACT:

Background

Wnt signal transduction pathway (Wnt STP) is a crucial intracellular pathway mainly due to its participation in important biological processes, functions, and diseases, i.e., embryonic development, stem-cell management, and human cancers among others. This is why Wnt STP is one of the highest researched signal transduction pathways. Study and analysis of its origin, expansion and gradual development to the present state as found in humans is one aspect of Wnt research. The pattern of development and evolution of the Wnt STP among various species is not clear till date. A phylogenetic tree created from Wnt STPs of multiple species may address this issue.

Results

In this respect, we construct a phylogenetic tree from modules of Wnt STPs of diverse species. We term i

SUBMITTER: Nayak L 

PROVIDER: S-EPMC4977476 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature