Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome.

ABSTRACT:

Unlabelled

Given their association with cardiovascular disease protection, there has been intense interest in understanding the biology of high density lipoproteins (HDL). HDL is actually a family of diverse particle types, each made up of discrete - but as yet undetermined - combinations of proteins drawn from up to 95 lipophilic plasma proteins. The abundant apolipoproteins (apo) of the A class (apoA-I, apoA-II and apoA-IV) have been proposed to act as organizing platforms for auxiliary proteins, but this concept has not been systematically evaluated. We assessed the impact of genetic knock down of each platform protein on the particle size distribution of auxiliary HDL proteins. Loss of apoA-I or apoA-II massively reduced HDL lipids and changed the plasma size pattern and/or abu

SUBMITTER: Gordon SM 

PROVIDER: S-EPMC4987197 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature