Manduca Contactin Regulates Amyloid Precursor Protein-Dependent Neuronal Migration.

ABSTRACT:

Unlabelled

Amyloid precursor protein (APP) was originally identified as the source of β-amyloid peptides that accumulate in Alzheimer's disease (AD), but it also has been implicated in the control of multiple aspects of neuronal motility. APP belongs to an evolutionarily conserved family of transmembrane proteins that can interact with a variety of adapter and signaling molecules. Recently, we showed that both APP and its insect ortholog [APPL (APP-Like)] directly bind the heterotrimeric G-protein Goα, supporting the model that APP can function as an unconventional Goα-coupled receptor. We also adapted a well characterized assay of neuronal migration in the hawkmoth, Manduca sexta, to show that APPL-Goα signaling restricts ectopic growth within the developing nervous system, analog

SUBMITTER: Ramaker JM 

PROVIDER: S-EPMC4987443 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature