ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis.

ABSTRACT: Atopic dermatitis (AD) is the most common inflammatory skin disease with no well-delineated cause or effective cure. Here we show that the p53 family member p63, specifically the ΔNp63, isoform has a key role in driving keratinocyte activation in AD. We find that overexpression of ΔNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with human AD. This includes pruritus, epidermal hyperplasia, aberrant keratinocyte differentiation, enhanced expression of selected cytokines and chemokines and the infiltration of large numbers of inflammatory cells including type 2  T-helper cells - features that are highly representative of AD dermatopathology. We further demonstrate several of these media

SUBMITTER: Rizzo JM 

PROVIDER: S-EPMC4987726 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature