Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) exerts its effects by modulating neural circuits involved in seizures. However, these networks remain incompletely characterized.

Objective

Investigate the effects of ATN DBS on network activity in a large animal model using 3-T fMRI.

Methods

Anesthetized swine underwent ATN DBS using stimulation parameters applied in the Stimulation of the Anterior Thalamus for the Treatment of Epilepsy (SANTE) trial. Stimulation amplitude, frequency, and temporal paradigm were varied and the resulting blood oxygen level-dependent signal was measured.

Results

ATN DBS resulted in activation within temporal, prefrontal, and sensorimotor cortex. An amplitude-dependent increase in cluster volume was obs

SUBMITTER: Gibson WS 

PROVIDER: S-EPMC5007150 | biostudies-literature | 2016 Sep-Oct

REPOSITORIES: biostudies-literature