Mapping the Regulatory Network for Salmonella enterica Serovar Typhimurium Invasion.

ABSTRACT:

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Salmonella enterica pathogenicity island 1 (SPI-1) encodes proteins required for invasion of gut epithelial cells. The timing of invasion is tightly controlled by a complex regulatory network. The transcription factor (TF) HilD is the master regulator of this process and senses environmental signals associated with invasion. HilD activates transcription of genes within and outside SPI-1, including six other TFs. Thus, the transcriptional program associated with host cell invasion is controlled by at least 7 TFs. However, very few of the regulatory targets are known for these TFs, and the extent of the regulatory network is unclear. In this study, we used complementary genomic approaches to map the direct regulatory targets of all 7 TFs. Our data reveal a highly complex a

SUBMITTER: Smith C 

PROVIDER: S-EPMC5013294 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature