Gout in Older Adults: The Atherosclerosis Risk in Communities Study.

ABSTRACT:

Background

It is unclear whether traditional and genetic risk factors in middle age predict the onset of gout in older age.

Methods

We studied the incidence of gout in older adults using the Atherosclerosis Risk in Communities study, a prospective U.S. population-based cohort of middle-aged adults enrolled between 1987 and 1989 with ongoing follow-up. A genetic urate score was formed from common urate-associated single nucleotide polymorphisms for eight genes. The adjusted hazard ratio and 95% confidence interval of incident gout by traditional and genetic risk factors in middle age were estimated using a Cox proportional hazards model.

Results

The cumulative incidence from middle age to age 65 was 8.6% in men and 2.5% in women; by age 75 the cumulative incidence was

SUBMITTER: Burke BT 

PROVIDER: S-EPMC5014186 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature