GenToS: Use of Orthologous Gene Information to Prioritize Signals from Human GWAS.

ABSTRACT: Genome-wide association studies (GWAS) evaluate associations between genetic variants and a trait or disease of interest free of prior biological hypotheses. GWAS require stringent correction for multiple testing, with genome-wide significance typically defined as association p-value <5*10-8. This study presents a new tool that uses external information about genes to prioritize SNP associations (GenToS). For a given list of candidate genes, GenToS calculates an appropriate statistical significance threshold and then searches for trait-associated variants in summary statistics from human GWAS. It thereby allows for identifying trait-associated genetic variants that do not meet genome-wide significance. The program additionally tests for enrichment of significant candidate gene associations

SUBMITTER: Hoppmann AS 

PROVIDER: S-EPMC5017755 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature