Role of histological regression grade after two neoadjuvant approaches with or without radiotherapy in locally advanced gastric cancer.

ABSTRACT:

Background

The degree of histopathological response after neoadjuvant therapy in locally advanced gastric cancer (GC) is a key determinant of patients' long-term outcome. We aimed to assess the pattern of histopathological regression after two neoadjuvant approaches and its impact on survival times.

Methods

Regression grade of the primary tumour (Becker criteria) and the degree of nodal response by a 4-point scale (grades A-D) were assessed. Grade A-true negative lymph nodes (LNs); grade B and C-infiltrated LNs with any or little evidence of nodal response; and grade D-complete pathological response in a previously infiltrated LN. A favourable pathological response was defined as Becker Ia-b and grade D.

Results

From 2004 to 2014, 80 patients with GC (cT3-4/N+ by CT-s

SUBMITTER: Martin-Romano P 

PROVIDER: S-EPMC5023782 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature