Impact of skin capsular distance on the performance of controlled attenuation parameter in patients with chronic liver disease.

ABSTRACT:

Background & aims

Controlled attenuation parameter (CAP) is a non-invasive method for evaluating hepatic steatosis. However, larger skin capsular distance (SCD) can affect the accuracy. The aim of this study was to investigate the impact of SCD on the diagnostic performance of CAP and liver stiffness measurement (LSM).

Methods

Of 101 patients with non-alcoholic fatty liver disease (NAFLD) and 280 patients with chronic hepatitis B (CHB) who underwent liver biopsy were prospectively recruited. CAP, LSM and SCD were performed using FibroScan with M probe. The areas under receiver operating characteristics curves (AUROCs) were calculated to determine the diagnostic efficacy. The optimal thresholds were defined by the maximum Youden index.

Results

SCD (B 30.34, P < 0.001)

SUBMITTER: Shen F 

PROVIDER: S-EPMC5023997 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature