Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia.

ABSTRACT: The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y chromosome haplogroups (Y-hgs) could modify the effects of autosomal variants on non-obstructive azoospermia (NOA), based on our previous genome-wide association study (GWAS), we conducted a genetic interaction analysis in GWAS subjects. Logistic regression analysis demonstrated a protective effect of Y-hg O3e(*) on NOA. Then, we explored the potential interaction between Y-hg O3e(*) and autosomal variants. Our results demonstrated that there was a suggestively significant interaction between Y-hg O3e(*) and rs11135484 on NOA (Pinter = 9.89 × 10(-5)). Bioinformatic analysis revealed that genes annotated by significant singl

SUBMITTER: Lu C 

PROVIDER: S-EPMC5024297 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature