Dataset Information

Subjective evaluation of the frequency of coffee intake and relationship to osteoporosis in Chinese men.

ABSTRACT:

Background

The main purpose of this study was to evaluate the associations between frequency of coffee intake and osteoporosis (OP) in a general Chinese male sample.

Methods

We conducted a large-scale, community-based, cross-sectional study to investigate the associations by using a self-report questionnaire to estimate the frequency of coffee intake. A total of 992 men were available for data analysis in this study. Multiple regression models controlling for confounding factors to include frequency of coffee intake variable were performed to investigate the relationships for OP.

Results

Positive correlations between frequency of coffee intake and T-score were reported (β = 0.211, P = 0.024). Multiple regression analysis indicated that the frequency of coffee intake was significantly associated with OP (P < 0.05 for model 1 and model 2). The men with moderate frequency of coffee intake had a lower prevalence of OP.

Conclusions

The findings indicated that consumption of coffee was independently and significantly associated with OP. The prevalence of OP was less frequent in Chinese men with moderate coffee intake.

Trial registration

ClinicalTrials.gov, NCT02451397.

SUBMITTER: Yu Q

PROVIDER: S-EPMC5026020 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Publications

Subjective evaluation of the frequency of coffee intake and relationship to osteoporosis in Chinese men.

Yu Qian Q Liu Zhong-Hua ZH Lei Tao T Tang Zihui Z

Journal of health, population, and nutrition 20160805 1

<h4>Background</h4>The main purpose of this study was to evaluate the associations between frequency of coffee intake and osteoporosis (OP) in a general Chinese male sample.<h4>Methods</h4>We conducted a large-scale, community-based, cross-sectional study to investigate the associations by using a self-report questionnaire to estimate the frequency of coffee intake. A total of 992 men were available for data analysis in this study. Multiple regression models controlling for confounding factors t ...[more]

PMID: 27495290

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Project description:BackgroundCoffee intake may lower prostate cancer risk and progression, but postdiagnosis outcomes by caffeine metabolism genotype are not well characterized.ObjectiveTo evaluate associations between coffee intake, caffeine metabolism genotype, and survival in a large, multicenter study of men with prostate cancer.Design, setting, and participantsData from The PRACTICAL Consortium database for 5727 men with prostate cancer from seven US, Australian, and European studies were included. The cases included had data available for the CYP1A2 -163C>A rs762551 single-nucleotide variant associated with caffeine metabolism, coffee intake, and >6 mo of follow-up.Outcome measurements and statistical analysisMultivariable-adjusted Cox proportional hazards models across pooled patient-level data were used to compare the effect of coffee intake (categorized as low [reference], high, or none/very low) in relation to overall survival (OS) and prostate cancer-specific survival (PCSS), with stratified analyses conducted by clinical disease risk and genotype.Results and limitationsHigh coffee intake appeared to be associated with longer PCSS (hazard ratio [HR] 0.85, 95% confidence interval [CI] 0.68-1.08; p = 0.18) and OS (HR 0.90, 95% CI 0.77-1.07; p = 0.24), although results were not statistically significant. In the group with clinically localized disease, high coffee intake was associated with longer PCSS (HR 0.66, 95% CI 0.44-0.98; p = 0.040), with comparable results for the group with advanced disease (HR 0.92, 95% CI 0.69-1.23; p = 0.6). High coffee intake was associated with longer PCSS among men with the CYP1A2 AA (HR 0.67, 95% CI 0.49-0.93; p = 0.017) but not the AC/CC genotype (p = 0.8); an interaction was detected (p = 0.042). No associations with OS were observed in subgroup analyses (p > 0.05). Limitations include the nominal statistical significance and residual confounding.ConclusionsCoffee intake was associated with longer PCSS among men with a CYP1A2 -163AA (*1F/*1F) genotype, a finding that will require further replication.Patient summaryIt is likely that coffee intake is associated with longer prostate cancer-specific survival in certain groups, but more research is needed to fully understand which men may benefit and why.

Dataset Information

Subjective evaluation of the frequency of coffee intake and relationship to osteoporosis in Chinese men.

Background

Methods

Results

Conclusions

Trial registration

Publications

Subjective evaluation of the frequency of coffee intake and relationship to osteoporosis in Chinese men.

Similar Datasets

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