Template-Based Modeling of Protein-RNA Interactions.

ABSTRACT: Protein-RNA complexes formed by specific recognition between RNA and RNA-binding proteins play an important role in biological processes. More than a thousand of such proteins in human are curated and many novel RNA-binding proteins are to be discovered. Due to limitations of experimental approaches, computational techniques are needed for characterization of protein-RNA interactions. Although much progress has been made, adequate methodologies reliably providing atomic resolution structural details are still lacking. Although protein-RNA free docking approaches proved to be useful, in general, the template-based approaches provide higher quality of predictions. Templates are key to building a high quality model. Sequence/structure relationships were studied based on a representative set o

SUBMITTER: Zheng J 

PROVIDER: S-EPMC5035060 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature