GABA deficiency in NF1: A multimodal [11C]-flumazenil and spectroscopy study.

ABSTRACT:

Objective

To provide a comprehensive investigation of the γ-aminobutyric acid (GABA) system in patients with neurofibromatosis type 1 (NF1) that allows understanding the nature of the GABA imbalance in humans at pre- and postsynaptic levels.

Methods

In this cross-sectional study, we employed multimodal imaging and spectroscopy measures to investigate GABA type A (GABAA) receptor binding, using [(11)C]-flumazenil PET, and GABA concentration, using magnetic resonance spectroscopy (MRS). Fourteen adult patients with NF1 and 13 matched controls were included in the study. MRS was performed in the occipital cortex and in a frontal region centered in the functionally localized frontal eye fields. PET and MRS acquisitions were performed in the same day.

Results

Patients with

SUBMITTER: Violante IR 

PROVIDER: S-EPMC5035153 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature