Non-invasive ventilation in obesity hypoventilation syndrome without severe obstructive sleep apnoea.

ABSTRACT:

Background

Non-invasive ventilation (NIV) is an effective form of treatment in patients with obesity hypoventilation syndrome (OHS) who have concomitant severe obstructive sleep apnoea (OSA). However, there is a paucity of evidence on the efficacy of NIV in patients with OHS without severe OSA. We performed a multicentre randomised clinical trial to determine the comparative efficacy of NIV versus lifestyle modification (control group) using daytime arterial carbon dioxide tension (PaCO2) as the main outcome measure.

Methods

Between May 2009 and December 2014 we sequentially screened patients with OHS without severe OSA. Participants were randomised to NIV versus lifestyle modification and were followed for 2 months. Arterial blood gas parameters, clinical symptoms, health-r

SUBMITTER: Masa JF 

PROVIDER: S-EPMC5036235 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature