Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress.

ABSTRACT:

Background

Psychological stress has long been recognized as a contributing factor to asthma symptom expression and disease progression. Yet, the neural mechanisms that underlie this relationship have been largely unexplored in research addressing the pathophysiology and management of asthma. Studies that have examined the mechanisms of this relationship in the periphery suggest that it is the superimposition of acute stress on top of chronic stress that is of greatest concern for airway inflammation.

Methods

We compared asthmatic individuals with high and low levels of chronic life stress in their neural and peripheral physiological responses to the Trier Social Stress Test and a matched control task. We used FDG-PET to measure neural activity during performance of the two t

SUBMITTER: Rosenkranz MA 

PROVIDER: S-EPMC5045317 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature