High sensitivity of gold nanoparticles co-doped with Gd₂O₃ mesoporous silica nanocomposite to nasopharyngeal carcinoma cells.

ABSTRACT: Nanoprobes for combined optical and magnetic resonance imaging have tremendous potential in early cancer diagnosis. Gold nanoparticles (AuNPs) co-doped with Gd₂O₃ mesoporous silica nanocomposite (Au/Gd@MCM-41) can produce pronounced contrast enhancement for T1 weighted image in magnetic resonance imaging (MRI). Here, we show the remarkably high sensitivity of Au/Gd@MCM-41 to the human poorly differentiated nasopharyngeal carcinoma (NPC) cell line (CNE-2) using fluorescence lifetime imaging (FLIM). The upconversion luminescences from CNE-2 and the normal nasopharyngeal (NP) cells (NP69) after uptake of Au/Gd@MCM-41 show the characteristic of two-photon-induced-radiative recombination of the AuNPs. The presence of the Gd³⁺ ion induces a much shorter luminesce

SUBMITTER: Wang H 

PROVIDER: S-EPMC5046069 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature