B cells gone rogue: the intersection of diffuse large B cell lymphoma and autoimmune disease.

ABSTRACT:

Introduction

Diffuse large B cell lymphoma (DLBCL) is characterized by genetic, genomic and clinical heterogeneity. Autoimmune diseases (AIDs) have recently been shown to represent significant risk factors for development of DLBCL.

Areas covered

Studies that examined the relationships between AIDs and lymphoma in terms of pathogenesis, genetic lesions, and treatment were identified in the MEDLINE database using combinations of medical subject heading (MeSH) terms. Co-authors independently performed study selection for inclusion based on appropriateness of the study question and nature of the study design and sample size. Expert commentary: Identification of AID as a substantial risk factor for DLBCL raises new questions regarding how autoimmunity influences lymphomagenesis a

SUBMITTER: Koff JL 

PROVIDER: S-EPMC5050045 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature