Ontology highlight
ABSTRACT:
SUBMITTER: Marina NM
PROVIDER: S-EPMC5052459 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Marina Neyssa M NM Smeland Sigbjørn S Bielack Stefan S SS Bernstein Mark M Jovic Gordana G Krailo Mark D MD Hook Jane M JM Arndt Carola C van den Berg Henk H Brennan Bernadette B Brichard Bénédicte B Brown Ken L B KLB Butterfass-Bahloul Trude T Calaminus Gabriele G Daldrup-Link Heike E HE Eriksson Mikael M Gebhardt Mark C MC Gelderblom Hans H Gerss Joachim J Goldsby Robert R Goorin Allen A Gorlick Richard R Grier Holcombe E HE Hale Juliet P JP Hall Kirsten Sundby KS Hardes Jendrik J Hawkins Douglas S DS Helmke Knut K Hogendoorn Pancras C W PCW Isakoff Michael S MS Janeway Katherine A KA Jürgens Heribert H Kager Leo L Kühne Thomas T Lau Ching C CC Leavey Patrick J PJ Lessnick Stephen L SL Mascarenhas Leo L Meyers Paul A PA Mottl Hubert H Nathrath Michaela M Papai Zsuzsanna Z Randall R Lor RL Reichardt Peter P Renard Marleen M Safwat Akmal Ahmed AA Schwartz Cindy L CL Stevens Michael C G MCG Strauss Sandra J SJ Teot Lisa L Werner Mathias M Sydes Matthew R MR Whelan Jeremy S JS
The Lancet. Oncology 20160825 10
<h4>Background</h4>We designed the EURAMOS-1 trial to investigate whether intensified postoperative chemotherapy for patients whose tumour showed a poor response to preoperative chemotherapy (≥10% viable tumour) improved event-free survival in patients with high-grade osteosarcoma.<h4>Methods</h4>EURAMOS-1 was an open-label, international, phase 3 randomised, controlled trial. Consenting patients with newly diagnosed, resectable, high-grade osteosarcoma aged 40 years or younger were eligible for ...[more]