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Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1-/?7 Mice.

ABSTRACT: Although it is clear that probiotics improve intestinal barrier function, little is known about the effects of probiotics on the aging intestine. We investigated effects of 10-week bacterial supplementation of Lactobacillus plantarum WCFS1, Lactobacillus casei BL23, or Bifidobacterium breve DSM20213 on gut barrier and immunity in 16-week-old accelerated aging Ercc1-/?7 mice, which have a median lifespan of ~20?weeks, and their wild-type littermates. The colonic barrier in Ercc1-/?7 mice was characterized by a thin (

SUBMITTER: van Beek AA 

PROVIDER: S-EPMC5054004 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Although it is clear that probiotics improve intestinal barrier function, little is known about the effects of probiotics on the aging intestine. We investigated effects of 10-week bacterial supplementation of <i>Lactobacillus plantarum</i> WCFS1, <i>Lactobacillus casei</i> BL23, or <i>Bifidobacterium breve</i> DSM20213 on gut barrier and immunity in 16-week-old accelerated aging <i>Ercc1<sup>-/Δ7</sup></i> mice, which have a median lifespan of ~20 weeks, and their wild-type littermates. The col  ...[more]

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