Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 ^-/Δ7 mice.

ABSTRACT:

Background

The use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting anti-inflammatory effects. The abundance of A. muciniphila is associated with a healthy gut in early mid- and later life. However, the effects of A. muciniphila on a decline in intestinal health during the aging process are not investigated yet. We supplemented accelerated aging Ercc1 ^-/Δ7 mice with A. muciniphila for 10 weeks and investigated histological, transcriptional and immunological aspects of intestinal health.

Results

The thickness of the colonic mucus layer increased about 3-fold after long-te

SUBMITTER: van der Lugt B 

PROVIDER: S-EPMC6408808 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature