Tunable and label-free virus enrichment for ultrasensitive virus detection using carbon nanotube arrays.

ABSTRACT: Viral infectious diseases can erupt unpredictably, spread rapidly, and ravage mass populations. Although established methods, such as polymerase chain reaction, virus isolation, and next-generation sequencing have been used to detect viruses, field samples with low virus count pose major challenges in virus surveillance and discovery. We report a unique carbon nanotube size-tunable enrichment microdevice (CNT-STEM) that efficiently enriches and concentrates viruses collected from field samples. The channel sidewall in the microdevice was made by growing arrays of vertically aligned nitrogen-doped multiwalled CNTs, where the intertubular distance between CNTs could be engineered in the range of 17 to 325 nm to accurately match the size of different viruses. The CNT-STEM significantly improv

SUBMITTER: Yeh YT 

PROVIDER: S-EPMC5055386 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature