Ontology highlight
ABSTRACT:
SUBMITTER: Hargan-Calvopina J
PROVIDER: S-EPMC5064860 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Developmental cell 20160909 1
Remodeling DNA methylation in mammalian genomes can be global, as seen in preimplantation embryos and primordial germ cells (PGCs), or locus specific, which can regulate neighboring gene expression. In PGCs, global and locus-specific DNA demethylation occur in sequential stages, with an initial global decrease in methylated cytosines (stage I) followed by a Tet methylcytosine dioxygenase (Tet)-dependent decrease in methylated cytosines that act at imprinting control regions (ICRs) and meiotic ge ...[more]