Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.

ABSTRACT: Central neuropathic pain (CNP) is a pervasive, debilitating problem that impacts thousands of people living with central nervous system disorders, including spinal cord injury (SCI). Current therapies for treating this type of pain are ineffective and often have dose-limiting side effects. Although opioids are one of the most commonly used CNP treatments, recent animal literature has indicated that administering opioids shortly after a traumatic injury can actually have deleterious effects on long-term health and recovery. In order to study the deleterious effects of administering morphine shortly after trauma, we employed our low thoracic (T13) dorsal root avulsion model (Spinal Neuropathic Avulsion Pain, SNAP). Administering a weeklong course of 10mg/kg/day morphine beginning 24h after S

SUBMITTER: Ellis A 

PROVIDER: S-EPMC5067205 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature