Apolipoprotein B Gene Polymorphisms and Dyslipidemia in HIV Infected Adult Zimbabweans.

ABSTRACT:

Background

Dyslipidemia does not occur in all HIV-infected or antiretroviral therapy-experienced patients suggesting role of host genetic factors but there is paucity of data on association between dyslipidemia and gene polymorphisms in Zimbabwe.

Objective

To determine association of lipoprotein levels and apolipoprotein B polymorphisms in HIV-infected adults.

Method

Demographic data were collected from 103 consenting patients; lipoprotein levels were determined and blood samples were successfully genotyped for both apolipoprotein B 2488C>T Xba1 and apolipoprotein B 4154G>A p.Gln4154Lys EcoR1 polymorphisms by real time polymerase chain reaction.

Results

Mean age of genotyped patients was 40.3 ± 10.1 years, 68% were female; prevalence of dys

SUBMITTER: Kodogo V 

PROVIDER: S-EPMC5070423 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature