Ontology highlight
ABSTRACT:
SUBMITTER: Vasmatzis G
PROVIDER: S-EPMC5070713 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Vasmatzis George G Johnson Sarah H SH Knudson Ryan A RA Ketterling Rhett P RP Braggio Esteban E Fonseca Rafael R Viswanatha David S DS Law Mark E ME Kip N Sertac NS Ozsan Nazan N Grebe Stefan K SK Frederick Lori A LA Eckloff Bruce W BW Thompson E Aubrey EA Kadin Marshall E ME Milosevic Dragana D Porcher Julie C JC Asmann Yan W YW Smith David I DI Kovtun Irina V IV Ansell Stephen M SM Dogan Ahmet A Feldman Andrew L AL
Blood 20120801 11
Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes with 5-year overall survival rates of only ∼ 35%. Improvement in outcomes has been stymied by poor understanding of the genetics and molecular pathogenesis of PTCL, with a resulting paucity of molecular targets for therapy. We developed bioinformatic tools to identify chromosomal rearrangements using genome-wide, next-generation sequencing analysis of mate-pair DNA libraries and applied these tools to 16 PTCL ...[more]