Ontology highlight
ABSTRACT:
SUBMITTER: Palomero T
PROVIDER: S-EPMC3963408 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20140112 2
Peripheral T cell lymphomas (PTCLs) are a heterogeneous and poorly understood group of non-Hodgkin lymphomas. Here we combined whole-exome sequencing of 12 tumor-normal DNA pairs, RNA sequencing analysis and targeted deep sequencing to identify new genetic alterations in PTCL transformation. These analyses identified highly recurrent epigenetic factor mutations in TET2, DNMT3A and IDH2 as well as a new highly prevalent RHOA mutation encoding a p.Gly17Val alteration present in 22 of 35 (67%) angi ...[more]