Pubertal timing and bone phenotype in early old age: findings from a British birth cohort study.

ABSTRACT:

Objectives

To investigate the effect of pubertal timing, assessed in adolescence, on bone size, strength and density in men and women in early old age.

Design

A British birth cohort study with prospective indicators of pubertal timing based on age at menarche, clinical assessment of pubertal stage, and growth tempo from serial height measures, and bone measures derived from peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) at 60-64 years of age among 866 women and 792 men.

Methods

A first set of regression models investigated the relationships between pubertal timing and bone size, strength and density, adjusting for current height and weight, smoking and adult socioeconomic position. To make an equivalent comparison between

SUBMITTER: Kuh D 

PROVIDER: S-EPMC5075580 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature