Precision Nanomedicine Using Dual PET and MR Temperature Imaging-Guided Photothermal Therapy.

ABSTRACT: Imaging-based techniques have enabled the direct integration of noninvasive imaging with minimally invasive interventions such as photothermal therapy (PTT) to improve the precision of treatment.

Methods

We investigated the feasibility of PTT for ovarian cancer under the guidance of PET and MR temperature imaging using copper sulfide nanoparticles (CuS NPs). The tumor distribution of the CuS NPs after systemic administration was assessed using highly sensitive, quantifiable PET imaging. Two wavelengths of near-infrared (NIR) lasers-808 and 980 nm-were tested for PTT using noninvasive MR temperature imaging real-time monitoring.

Results

The in vivo studies revealed that the 980-nm NIR laser had better photothermal effects than the 808-nm NIR laser. These results were in accord

SUBMITTER: Zhou M 

PROVIDER: S-EPMC5093070 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature