A Short Synthesis of Aphanamol I in Both Racemic and Enantiopure Forms.

ABSTRACT: A short synthesis of the biologically active sesquiterpene natural product (+)-aphanamol I in both racemic and enantiopure forms is reported. Key steps include: a catalytic enantioselective conjugate addition, an oxidative radical cyclization, and a ring-expanding Claisen rearrangement.

SUBMITTER: Ferrara SJ 

PROVIDER: S-EPMC5096262 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature