Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA_A Receptor Positive Allosteric Modulator.

ABSTRACT: Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor response and low remission rates. Recent research has implicated the GABAergic system in the pathophysiology of depression, including deficits in interneurons targeting the dendritic compartment of cortical pyramidal cells. Objectives: The present study evaluates whether SH-053-2'F-R-CH3 (denoted "α5-PAM"), a positive allosteric modulator selective for α5-subunit containing GABA_A receptors found predominantly on cortical pyramidal cell dendrites, has anti-stress effects. Methods: Female and male C57BL6/J mice were exposed to unpredictable chronic mild stress (UCMS)

SUBMITTER: Piantadosi SC 

PROVIDER: S-EPMC5118774 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature