The GABA_B Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats.

ABSTRACT: GABAergic signaling is involved in modulating the reinforcing properties of alcohol, and GABA_B receptors have been proposed as a potential target for clinical treatment of alcoholism. The orthosteric GABA_B receptor agonist baclofen has been shown to suppress operant self-administration of alcohol in animals and alcohol use in alcohol-dependent patients, but its utility is limited by a narrow therapeutic index. We tested the effects of ADX71441, a novel GABA_B receptor positive allosteric modulator, on alcohol-related behaviors in rats. We first assessed the effects of ADX71441 (1, 3, 10 and 30 mg/kg, I.P.) on both non-dependent and dependent male Wistar rats trained to self-administer 20% alcohol. We then determined the effects of ADX71441 on stress-induced

SUBMITTER: Augier E 

PROVIDER: S-EPMC5520784 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature