Activation of GABA_B receptors in central amygdala attenuates activity of PKCδ + neurons and suppresses punishment-resistant alcohol self-administration in rats.

ABSTRACT: Alcohol use despite negative consequences is a core phenomenon of alcohol addiction. We recently used alcohol self-administration that is resistant to footshock punishment as a model of this behavior, and found that activity of PKCδ + GABAergic neurons in the central amygdala (CeA) is a determinant of individual susceptibility for punishment resistance. In the present study, we examined whether activation of GABA_B receptors in CeA can attenuate the activity of PKCδ + neurons in this region, and whether this will result in suppression of punishment- resistant alcohol self-administration in the minority of rats that show this behavior. Systemic administration of the clinically approved GABA_B agonist baclofen (1 and 3 mg/kg) dose- dependently reduced punishment-resistant

SUBMITTER: Domi E 

PROVIDER: S-EPMC10354045 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature