Meal replacements followed by topiramate for the treatment of adolescent severe obesity: A pilot randomized controlled trial.

ABSTRACT:

Objective

To assess the safety and efficacy of short-term meal replacement therapy followed by topiramate for body mass index (BMI) reduction in adolescents with severe obesity.

Methods

Adolescents (ages 12-18 years) with severe obesity (BMI ≥1.2 times the 95th percentile or BMI ≥35 kg/m² ) were recruited for this double-blind, randomized, placebo-controlled trial. Participants completed 4 weeks of meal replacement therapy followed by randomization (1:1) to either 24 weeks of topiramate 75 mg/day or placebo. Mean changes were compared between groups.

Results

Thirty adolescents (mean age 15.2 ± 1.7 years, mean BMI 40.3 ± 4.6 kg/m² ) completed the meal replacement phase and were randomized; 21 completed the study. The difference in mean percent cha

SUBMITTER: Fox CK 

PROVIDER: S-EPMC5125846 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature