Constitutive Glycolytic Metabolism Supports CD8⁺ T Cell Effector Memory Differentiation during Viral Infection.

ABSTRACT: Extensive metabolic changes accompany T cell activation, including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest that subsequent return to reliance on oxidative phosphorylation and increasing spare respiratory capacity are essential for the differentiation of memory CD8⁺ T cells. In contrast, we found that constitutive glycolytic metabolism and suppression of oxidative phosphorylation in CD8⁺ T cells, achieved by conditional deletion of hypoxia-inducible factor regulator Vhl, accelerated CD8⁺ memory cell differentiation during viral infection. Despite sustained glycolysis, CD8⁺ memory cells emerged that upregulated key memory-associated cytokine receptors and transcription factors and showed a heighte

SUBMITTER: Phan AT 

PROVIDER: S-EPMC5130099 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature