IL-33 activates mTORC1 and modulates glycolytic metabolism in CD8⁺ T cells.

ABSTRACT: Interleukin (IL)-33, a member in the IL-1 family, plays a central role in innate and adaptive immunity; however, how IL-33 mediates cytotoxic T-cell regulation and the downstream signals remain elusive. In this study, we found increased mouse IL-33 expression in CD8⁺ T cells following cell activation via anti-CD3/CD28 stimulation in vitro or lymphocytic choriomeningitis virus (LCMV) infection in vivo. Our cell adoptive transfer experiment demonstrated that extracellular, but not nuclear, IL-33 contributed to the activation and proliferation of CD8⁺ , but not CD4⁺ T effector cells in LCMV infection. Importantly, IL-33 induced mTORC1 activation in CD8⁺ T cells as evidenced by increased phosphorylated S6 ribosomal protein (p-S6) levels both in vitro

SUBMITTER: Liang Y 

PROVIDER: S-EPMC9112898 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature