IL-36β Promotes CD8⁺ T Cell Activation and Antitumor Immune Responses by Activating mTORC1.

ABSTRACT: Cytokine-amplified functional CD8⁺ T cells ensure effective eradication of tumors. Interleukin 36α (IL-36α), IL-36β, and IL-36γ share the same receptor complex, composed of the IL-36 receptor (IL-36R), and IL-1RAcP. Recently, we revealed that IL-36γ greatly promoted CD8⁺ T cell activation, contributing to antitumor immune responses. However, the underlying mechanism of IL-36-mediated CD8⁺ T cell activation remains understood. In the current study, we proved that IL-36β had the same effect on CD8⁺ T cell as IL-36γ, and uncovered that IL-36β significantly activated mammalian target of rapamycin complex 1 (mTORC1) of CD8⁺ T cells. When mTORC1 was inhibited by rapamycin, IL-36β-stimulated CD8⁺ T cell activation and expansion was

SUBMITTER: Zhao X 

PROVIDER: S-EPMC6692458 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature