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Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions.

ABSTRACT: Atherosclerosis is a chronic inflammatory disease with complex pathological processes. MicroRNA-33 (miR-33), a novel non-coding RNA that coexpresses with sterol regulatory element-binding proteins (SREBPs), affects macrophage actions to prevent atherosclerosis. Fibroblast growth factor 21 (FGF21) is an important regulator of lipid metabolism, especially for macrophage-related cholesterol export, but the mechanism is not fully studied. Interestingly, FGF21 has been evidenced to prevent atherosclerosis via inhibiting SREBP-2 expression. Therefore, we speculate that FGF21 may be a potential regulator for miR-33 with an aim of insight into novel anti-atherosclerotic mechanisms and research fields.

SUBMITTER: Guo Y 

PROVIDER: S-EPMC5134291 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Fibroblast growth factor 21 potentially inhibits microRNA-33 expression to affect macrophage actions.

Guo Yuan Y   Luo Fei F   Yi Yuhong Y   Xu Danyan D  

Lipids in health and disease 20161201 1

Atherosclerosis is a chronic inflammatory disease with complex pathological processes. MicroRNA-33 (miR-33), a novel non-coding RNA that coexpresses with sterol regulatory element-binding proteins (SREBPs), affects macrophage actions to prevent atherosclerosis. Fibroblast growth factor 21 (FGF21) is an important regulator of lipid metabolism, especially for macrophage-related cholesterol export, but the mechanism is not fully studied. Interestingly, FGF21 has been evidenced to prevent atheroscle  ...[more]

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