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Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.

ABSTRACT:

Aim

To evaluate the potential of tumor-targeted nanoprobe, N-(2-hydroxypropyl)methacrylamide copolymer-conjugated zinc protoporphyrin (PZP) for photodynamic therapy (PDT) and tumor imaging.

Materials & methods

Different tumor models including carcinogen-induced cancer were used, PZP was intravenously injected followed by irradiation with xenon or blue fluorescent light on tumor.

Results

One PZP 20 mg/kg (ZnPP equivalent) dose with two or three treatments of light at an intensity of ≥20 J/cm² caused necrosis and disappearance of most tumors (>70%) in different tumor models. We also confirmed PZP-based tumor imaging in carcinogen-induced breast tumor and colon cancer models.

Conclusion

These findings support the potential application of PZP as a tumor-selective nanoprobe for PDT as well as tumor imaging, by virtue of the enhanced permeability and retention effect.

SUBMITTER: Fang J

PROVIDER: S-EPMC5137960 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin.

Fang Jun J Liao Long L Yin Hongzhuan H Nakamura Hideaki H Subr Vladimir V Ulbrich Karel K Maeda Hiroshi H

Future science OA 20151101 3

<h4>Aim</h4>To evaluate the potential of tumor-targeted nanoprobe, <i>N</i>-(2-hydroxypropyl)methacrylamide copolymer-conjugated zinc protoporphyrin (PZP) for photodynamic therapy (PDT) and tumor imaging.<h4>Materials & methods</h4>Different tumor models including carcinogen-induced cancer were used, PZP was intravenously injected followed by irradiation with xenon or blue fluorescent light on tumor.<h4>Results</h4>One PZP 20 mg/kg (ZnPP equivalent) dose with two or three treatments of light at ...[more]

PMID: 28031879

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