Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans.

ABSTRACT:

Context

Prediabetes is a heterogeneous disorder classified on the basis of fasting glucose concentrations and 2-hour glucose tolerance.

Objective

We sought to determine the relative contributions of insulin secretion and action to the pathogenesis of isolated impaired glucose tolerance (IGT).

Design

The study consisted of an oral glucose tolerance test and a euglycemic clamp performed in two cohorts matched for anthropometric characteristics and fasting glucose but discordant for glucose tolerance.

Setting

An inpatient clinical research unit at an academic medical center.

Patients or other participants

Twenty-five subjects who had normal fasting glucose (NFG) and normal glucose tolerance (NGT) and 19 NFG/IGT subjects participated in this study.

Interv

SUBMITTER: Varghese RT 

PROVIDER: S-EPMC5155694 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature