Immunotherapy with Aducanumab Restores Calcium Homeostasis in Tg2576 Mice.

ABSTRACT: Calcium homeostasis plays a major role in maintaining neuronal function under physiological conditions. Amyloid-β (Aβ) initiates pathological processes that include disruption in intracellular calcium levels, so amelioration of the calcium alteration could serve as an indirect functional indicator of treatment efficacy. Therefore, calcium dynamics were used as a measure of functional outcome. We evaluated the effects of the anti-Aβ antibody aducanumab on calcium homeostasis and plaque clearance in aged Tg2576 mice with in vivo multiphoton imaging. Acute topical application of aducanumab to the brain resulted in clearance of amyloid plaques. Although chronic systemic administration of aducanumab in 22-month-old mice did not clear existing plaques, calcium overload was ameliorated over time.

SUBMITTER: Kastanenka KV 

PROVIDER: S-EPMC5157102 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature