GPS-PAIL: prediction of lysine acetyltransferase-specific modification sites from protein sequences.

ABSTRACT: Protein acetylation catalyzed by specific histone acetyltransferases (HATs) is an essential post-translational modification (PTM) and involved in the regulation a broad spectrum of biological processes in eukaryotes. Although several ten thousands of acetylation sites have been experimentally identified, the upstream HATs for most of the sites are unclear. Thus, the identification of HAT-specific acetylation sites is fundamental for understanding the regulatory mechanisms of protein acetylation. In this work, we first collected 702 known HAT-specific acetylation sites of 205 proteins from the literature and public data resources, and a motif-based analysis demonstrated that different types of HATs exhibit similar but considerably distinct sequence preferences for substrate recognition. Usi

SUBMITTER: Deng W 

PROVIDER: S-EPMC5177928 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature