Ontology highlight
ABSTRACT:
SUBMITTER: Peters DT
PROVIDER: S-EPMC5193468 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Biochemistry 20160901 36
Lin28A is a post-transcriptional regulator of gene expression that interacts with and negatively regulates the biogenesis of let-7 family miRNAs. Recent data suggested that Lin28A also binds the putative tumor suppressor miR-363, a member of the 106~363 cluster of miRNAs. Affinity for this miRNA and the stoichiometry of the protein-RNA complex are unknown. Characterization of human Lin28's interaction with RNA has been complicated by difficulties in producing stable RNA-free protein. We have eng ...[more]