Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM.

ABSTRACT: It has been contended that any observed difference of the corpus callosum (CC) size between men and women is not sex-related but brain-size-related. A recent report, however, showed that the midsagittal CC area was significantly larger in women in 37 brain-size-matched pairs of normal young adults. Since this constituted strong evidence of sexual dimorphism and was obtained from publicly available data in OASIS, we examined volume differences within the CC and in other white matter using voxel-based morphometry (VBM). We created a three-dimensional region of interest of the CC and measured its volume. The VBM statistics were analyzed by permutation test and threshold-free cluster enhancement (TFCE) with the significance levels at FWER < 0.05. The CC volume was significantly larger in women

SUBMITTER: Shiino A 

PROVIDER: S-EPMC5206615 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature