3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes.

ABSTRACT: The vast noncoding portion of the human genome harbors a rich array of functional elements and disease-causing regulatory variants. Recent high-throughput chromosome conformation capture studies have outlined the principles of these elements interacting and regulating the expression of distal target genes through three-dimensional (3D) chromatin looping. Here we present 3DSNP, an integrated database for annotating human noncoding variants by exploring their roles in the distal interactions between genes and regulatory elements. 3DSNP integrates 3D chromatin interactions, local chromatin signatures in different cell types and linkage disequilibrium (LD) information from the 1000 Genomes Project. 3DSNP provides informative visualization tools to display the integrated local and 3D chromatin

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5210526 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature