Stromal Cell Subsets Directing Neonatal Spleen Regeneration.

ABSTRACT: Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads to a complete cessation of lymph node (LN) and Peyer's patch development, identifying LTo as a key stromal population for lymphoid tissue organogenesis. However, little is known about the equivalent stromal cells that induce spleen development. Here, by dissociating neonatal murine spleen stromal tissue for re-aggregation and transplant into adult mouse recipients, we have identified a MAdCAM-1⁺CD31⁺CD201⁺ spleen stromal organizer cell-type critical for new tissue formation. This

SUBMITTER: Tan JK 

PROVIDER: S-EPMC5220291 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature