Ontology highlight
ABSTRACT:
SUBMITTER: Cho GS
PROVIDER: S-EPMC5232412 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cell reports 20170101 2
Pluripotent stem cells (PSCs) offer unprecedented opportunities for disease modeling and personalized medicine. However, PSC-derived cells exhibit fetal-like characteristics and remain immature in a dish. This has emerged as a major obstacle for their application for late-onset diseases. We previously showed that there is a neonatal arrest of long-term cultured PSC-derived cardiomyocytes (PSC-CMs). Here, we demonstrate that PSC-CMs mature into adult CMs when transplanted into neonatal hearts. PS ...[more]